Vitamin D and evolution: Pharmacologic implications
نویسندگان
چکیده
منابع مشابه
Vitamin D supplementation: a pharmacologic perspective.
PURPOSE OF REVIEW Vitamin D supplementation is expected to increase as clinicians try to optimize their patients' vitamin D status. This review integrates newer information into a perspective on vitamin D disposition and effect. RECENT FINDINGS Vitamin D is being considered for indications beyond bone health. The limited dose-response data vary by indication, but generally target a goal serum...
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Evidence exists that vitamin D has a potential antimicrobial activity and its deficiency has deleterious effects on general well-being and longevity. Vitamin D may reduce the risk of infection through multiple mechanisms. Vitamin D boosts innate immunity by modulating production of anti-microbial peptides (AMPs) and cytokine response. Vitamin D and its analogues via these mechanisms are playing...
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Vitamin D deficiency is a common medical problem worldwide and its prevalence rises along with latitude, obesity, sedentary lifestyle, limited sunlight exposure and aging. A great body of evidence has shown that patients with vitamin D deficiency have increased cardiovascular risks and total mortality. Conversely, the presence of comorbidities progressive with age such as abdominal obesity, ins...
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THE EVIDENCE FOR NEWLY DISCOVERED ROLES FOR VITAMIN D An important clue to roles of vitamin D beyond calcium homeostasis came with the finding that the 1,25dihydroxyvitamin D nuclear receptor is present in most tissues. A reevaluation of the physiological and pharmacological actions of vitamin D produced evidence that vitamin D can regulate the immune system and thereby is implicated in several...
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ژورنال
عنوان ژورنال: Biochemical Pharmacology
سال: 2020
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2019.07.024